Understanding Naloxone:​
A Life-Saving Medication

Naloxone, also known as Narcan or Evzio, is a safe, FDA-approved medication that can reverse opioid overdoses within minutes. In a time when opioid overdoses are a major threat, understanding how naloxone works, recognizing the signs of an overdose, and knowing how to use it effectively can be life-saving.

How Naloxone Works

How Naloxone Works

Opioids, such as OxyContin or heroin, bind to specific receptors in the brain, spinal cord, and gastrointestinal tract. This binding not only minimizes the body's perception of pain but also induces feelings of euphoria. However, opioids also affect vital systems responsible for regulating mood, blood pressure, and breathing. During an overdose, the opioid suppresses the respiratory system to the point where breathing stops completely, which can result in a fatal outcome.

Naloxone, a true lifesaver, acts as an opioid antagonist. It competes with the opioid, binding to the same receptors and displacing the opioid in the process. This action temporarily reverses the harmful effects of the opioid, allowing the individual to begin breathing again within a matter of minutes. It's crucial to emphasize that naloxone can make a life-or-death difference during an overdose crisis.

Who's at Risk of an Opioid Overdose?

Understanding who is at risk of an opioid overdose is crucial for proactive intervention. The following groups are particularly vulnerable:

  • People Addicted to Prescription or Illegal Opioids: Individuals struggling with addiction to prescription or illegal opioids face a higher risk of overdose.
  • High-Dose Prescription Opioid Users: Those taking prescription opioids, especially in high doses, are susceptible to overdose incidents.
  • Combining Opioids with Other Substances: People who use alcohol, anti-depressants, or benzodiazepines in conjunction with opioids are at an increased risk.
  • Early Recovery: Individuals who have recently stopped using opioids or are in the early stages of recovery have a lowered tolerance, making any opioid use potentially fatal.
Broader Access to Naloxone

Broader Access to Naloxone Saves Lives

Naloxone access programs have received support from prominent organizations and figures in public health. It's essential to debunk the misconception that naloxone access encourages drug use. Numerous studies have shown that naloxone availability does not lead to increased opioid misuse or overdoses.

In conclusion, naloxone is a powerful tool in the battle against opioid overdoses. It's imperative that everyone in a position to save a life carry naloxone, whether they are first responders, healthcare workers, or everyday individuals. Science and compassion should guide public health policies, and naloxone access is a caring and responsible measure to protect lives.

Identifying an Opioid Overdose

Recognizing the signs of an opioid overdose is crucial for timely intervention. Look out for the following indicators:

  • Blue or Grey Lips or Fingertips
  • Snoring or Gurgling Sounds
  • Pinpoint Pupils
  • Unresponsiveness or Severe Sleepiness: Attempts to wake the person up with a loud voice or firm rub on the chest are unsuccessful.
  • Breathing Problems: Slow or shallow breathing.
  • Floppy Arms or Legs

How to Administer Naloxone

Watch a Naloxone Training

Before obtaining naloxone, it's advisable to watch a training video to understand the correct administration technique. Training resources are available online.

Carry Naloxone

Research shows bystanders are more likely to use naloxone than perform CPR. Carrying naloxone can make a life-saving difference. Will you take the pledge?

Obtaining Naloxone in Your Community

Use the Harm Reduction Coalition's naloxone finder to locate free supplies. Contact your local health department to learn about programs in your area.

Getting Naloxone at the Pharmacy

FDA-approved nasal spray (Narcan) and auto-injector (Evzio) are available in most states without a prescription. Ask your pharmacy about availability and insurance coverage.

Cost Considerations

Narcan may cost $20–$125 for a two-pack depending on insurance. Evzio may be free for those with insurance, with cost-assistance options for the uninsured.

ACE Foundation